The Madonna Inn is a motel in San Luis Obispo, California. Opened for business in 1958, it quickly became a landmark on the Central Coast of California. It was created by Alex Madonna, a successful construction magnate and entrepreneur, and his wife Phyllis. The inn includes a restaurant and bakery, and is located on the west side of US Route 101 and situated on the lower eastern portion of Cerro San Luis Obispo.
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